From hemangioblast to hematopoietic stem cell: An endothelial connection?

被引：90

作者：

Jaffredo, T

Nottingham, W

Liddiard, K

Bollerot, K

Pouget, C

de Bruijn, M ^{[1
]}

机构：

[1] John Radcliffe Hosp, MRC, Mol Haematol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] Univ Paris 06, Dev Biol Lab, CNRS, UMR7622, F-75252 Paris, France

来源：

EXPERIMENTAL HEMATOLOGY | 2005年 / 33卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.exphem.2005.06.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The developmental origin of hematopoietic stem cells has been the subject of much research. Now that the developmental link between the hematopoietic system and the vasculature has been well established, questions remain regarding the precise cellular origin of definitive hematopoietic cells and at what point they branch off from the endothelial lineage. Do they emerge directly from a hemangioblast-type cell, similar to what is proposed for primitive yolk sac hematopoiesis, or are they generated via an endothelial intermediate, the hemogenic endothelium? In this review, we will give an overview of the data obtained from the mouse and avian models on the cellular origins of the hematopoietic system. (c) 2005 International Society for Experimental Hematology. Published by Elsevier Inc.

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页码：1029 / 1040

页数：12

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