Chemopreventive activity of isoquinoline alkaloids from Corydalis plants

被引:27
作者
Ito, C
Itoigawa, M
Tokuda, H
Kuchide, M
Nishino, H
Furukawa, H [1 ]
机构
[1] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan
[2] Tokyo Gakuen Univ, Miyoshi, Aichi, Japan
[3] Kyoto Prefectural Univ Med, Dept Biochem, Kyoto 602, Japan
关键词
D O I
10.1055/s-2001-15815
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Eighteen isoquinoline alkaloids including protoberberines (1-12), benzophenanthridines (13-16) and an aporphine (17) isolated from plants of Corydalis species (Fumariaceae) were tested for inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. In a primary screening test, all of the isoquinoline alkaloids showed inhibitory activity with the IC50 values being in the range of 140-410 mol ratio/32 pmol TPA. The data demonstrate that these isoquinoline alkaloids might be valuable as anti-tumor promoters.
引用
收藏
页码:473 / 475
页数:3
相关论文
共 8 条
  • [1] Gatto B, 1996, CANCER RES, V56, P2795
  • [2] ALKALOIDS FROM CORYDALIS
    ITO, C
    MIZUNO, T
    WU, TS
    FURUKAWA, H
    [J]. PHYTOCHEMISTRY, 1990, 29 (06) : 2044 - 2045
  • [3] New carbazole alkaloids from Clausena anisata with antitumor promoting activity
    Ito, C
    Katsuno, S
    Itoigawa, M
    Ruangrungsi, N
    Mukainaka, T
    Okuda, M
    Kitagawa, Y
    Tokuda, H
    Nishino, H
    Furukawa, H
    [J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (01): : 125 - 128
  • [4] ITO C, 2001, J NAT PRODUCTS, V63, P1344
  • [5] Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine
    Kim, SA
    Kwon, Y
    Kim, JH
    Muller, MT
    Chung, IK
    [J]. BIOCHEMISTRY, 1998, 37 (46) : 16316 - 16324
  • [6] Murakami A, 1996, BIOSCI BIOTECH BIOCH, V60, P1, DOI 10.1271/bbb.60.1
  • [7] Suffness, 1985, ALKALOIDS, V25, P178
  • [8] STUDIES ON THE INHIBITORY EFFECTS OF SOME ACRIDONE ALKALOIDS ON EPSTEIN-BARR-VIRUS ACTIVATION
    TAKEMURA, Y
    JUICHI, M
    ITO, C
    FURUKAWA, H
    TOKUDA, H
    [J]. PLANTA MEDICA, 1995, 61 (04) : 366 - 368