Paradoxical expression of anti-apoptotic and MRP genes on cancer stem-like cell isolated from TJ905 glioblastoma multiforme cell line

被引：18

作者：

Jin, Feng ^{[2
]}

Zhao, Lei ^{[1
]}

Zhao, Hong-Yang ^{[2
]}

Guo, Shou-Gang ^{[3
]}

Feng, Jun ^{[2
]}

Jiang, Xiao-Bing ^{[2
]}

Zhang, Shu-Ling ^{[1
]}

Wei, Yu-Jia ^{[2
]}

Fu, Rong ^{[2
]}

Zhao, Jia-Shan ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Hepatol & Infect Dis, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Neurosurg, Wuhan 430022, Peoples R China

[3] Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 04期

关键词：

cancer stem-like cell; TJ905 glioblastoma multiforme cell line; Livin; Survivin; multidrug resistance-associated protein;

D O I：

10.1080/07357900701788064

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Existence of cancer stem cell is regarded as a main reason for metastasis and/or recurrences. In this study, the cancer stem-like cell derived from TJ905 glioblastoma multiforme cell line was isolated successfully. However, it was observed that generating rate of the cancer stem-like cells was lower than that of TJ905 cells, that expression of the anti-apoptotic and multidrug resistance-associated protein (MRP) genes were paradoxical to the literatures, which showed the uncertainty of cancer stem cells, and that some stem cell was not the solo factor to maintain tumor growth and resist apoptosis and anti-tumor drugs.

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收藏

页码：338 / 343

页数：6

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