Death in the third dimension: apoptosis regulation and tissue architecture

被引:126
作者
Zahir, N
Weaver, VM
机构
[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
[2] Univ Penn, Inst Med & Engn, Vagelos Res Lab 1170, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Pathol, Philadelphia, PA 19104 USA
[4] Inst Med & Engn, Vagelos Res Lab 1170, Philadelphia, PA 19104 USA
关键词
D O I
10.1016/j.gde.2003.12.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Tissue development, homeostasis and tumor pathogenesis all depend upon a complex dialogue between multiple cell types operating within a dynamic three-dimensional (3D) tissue extracellular matrix microenvironment. A major issue is whether the spatial organization of a cell within this 3D tissue microenvironment could modulate cell responsiveness to regulate cell fate decisions such as survival, and if so how. Classic developmental model systems and transgenic animals are instructive but pose special challenges for investigators conducting signaling studies and biochemical assays in tissues. As an alternative, 3D culture model systems exist in which cell-adhesion dependent tissue architecture, heterotypic cell-cell interactions and tissue differentiation can be recapitulated with good fidelity. 3D cell culture models are slowly revealing how tissue architecture can dramatically influence how a cell responds to exogenous stimuli to modify its apoptotic behavior and hence should prove instrumental for identifying novel cell death pathways.
引用
收藏
页码:71 / 80
页数:10
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