Differential associations of statin and fibrate treatment with carotid arterial remodeling

被引：11

作者：

Chironi, G

Simon, A

Gariepy, R

Balice, M

Del-Pino, M

Levenson, J

机构：

[1] Hop Broussais, Ctr Med Prevent Cardiovasc, AP HP, F-75674 Paris, France

[2] Fac Med Paris 5, Paris, France

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2005年 / 18卷 / 11期

关键词：

arterial remodeling; cardiovascular risk factors; carotid artery; fibrate derivatives; intima-media thickness; statins;

D O I：

10.1016/j.amjhyper.2005.05.019

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Background: The effects of statins on intima-media thickness (IMT) are well, documented, whereas those of fibrates are unknown. Therefore we compared IMT under treatment with each class of drugs. Methods: We studied a cohort of consecutive dyslipidemic subjects treated with statin (n = 29 1) or fibrate (n = 82) drugs. Fibrate-treated subjects were matched with the same number of statin-treated subjects to obtain two subgroups of similar demographic and risk factors including LDL cholesterol. Common carotid far wall IMT and lumen diameter were measured by ultrasonography. Results: In the entire study population, IMT was greater in the fibrate group than in the statin group (P <.001), even after adjustment for LDL cholesterol and other covariates (P <.05). In the matched groups, IMT was greater in fibrate group than in the statin group (P <.01), even after adjustment for LDL cholesterol and other covariates including treatment duration (P <.01). The IMT correlated positively with treatment duration in the fibrate group (P < 0.05) but not in the statin group. In addition, IMT correlated positively with carotid lumen diameter in both the fibrate and statin groups (P <.05, P <.01) but with a lower slope in the former (P <.05). Conclusions: In this study fibrate treatment was associated with greater IMT, steeper IMT-time relationship, and lower compensatory carotid enlargement than was statin treatment. These differences were not explained by differences in LDL cholesterol. Am J Hypertens 2005;18: 1476-1481 (c) 2005 American Journal of Hypertension, Ltd.

引用

页码：1476 / 1481

页数：6

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