Gastric-mucous membrane protection activity of coptisine derivatives

被引：33

作者：

Hirano, H

Osawa, E

Yamaoka, Y

Yokoi, T

机构：

[1] Kobe Gakuin Univ, Fac Pharmaceut Sci, Nishi Ku, Kobe, Hyogo 6512180, Japan

[2] Kobe Gakuin Univ, High Technol Res Ctr, Nishi Ku, Kobe, Hyogo 6512180, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 11期

关键词：

coptisine; gastric-mucous membrane protection; structure-activity relationship;

D O I：

10.1248/bpb.24.1277

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Coptisine and 8-oxocoptisine were isolated as principles of the gastric-mucous membrane protection from Coptidis rhizoma. The two compounds showed stronger activity than cimetidine and sucralfate. We prepared several derivatives having a partial structure of coptisine from commercially available starting materials. The compounds obtained were tested for gastric-mucous membrane protective activity and a correlation between activity and structure was studied. Our results suggest that the partial charge of the catechol skeleton is related to activity.

引用

页码：1277 / 1281

页数：5

共 10 条

[1]

SYNTHESIS OF ISOQUINOLINES, INDOLES AND BENZTHIOPHEN BY AN IMPROVED POMERANZ-FRITSCH REACTION, USING BORON TRIFLUORIDE IN TRIFLUOROACETIC ANHYDRIDE [J].