AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma

被引：80

作者：

Rivera, E

Arrieta, O ^{[1
]}

Guevara, P

Duarte-Rojo, A

Sotelo, J

机构：

[1] Natl Inst Neurol & Neurosurg Mexico, Neuroimmunol Unit, Mexico City 14269, DF, Mexico

[2] Natl Autonomous Univ Mexico, Mexico City 14269, DF, Mexico

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 85卷 / 09期

关键词：

losartan; angiotensin; glioma; brain tumour; angiogenesis;

D O I：

10.1054/bjoc.2001.2102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignancy of neoplasms is partly dependent on angiogenesis. Angiotensin II mediates angiogenesis and transcription of growth-related factors through stimulation of the AT1 receptor (AT1 R). Losartan, a drug used mostly for treatment of hypertension, binds strongly to this receptor. We found the presence of AT1 receptor on C6 glioma cells and studied the effect of Losartan on the growth and angiogenesis of C6 rat glioma; Losartan in dose of 80 mg/kg induced 79% reduction of tumoural volume with a significant decrease of vascular density, mitotic index and cell proliferation. Our results demonstrate the conspicuous presence of AT1R in malignant glial cells and a favourable therapeutic response in experimental glioma by selective blockage of the AT1 receptor. (C) 2001 Cancer Research Campaign.

引用

页码：1396 / 1399

页数：4

共 36 条

[1] Protamine inhibits angiogenesis and growth of C6 rat glioma; a synergistic effect when combined with carmustine [J].