Medical implications of benzimidazole derivatives as drugs designed for targeting DNA and DNA associated processes

被引：140

作者：

Bhattacharya, Santanu ^{[1
,2
]}

Chaudhuri, Padmaparna ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

[2] Jawaharlal Nehru Ctr Adv Sci Res, Chem Biol Unit, Bangalore 560012, Karnataka, India

来源：

CURRENT MEDICINAL CHEMISTRY | 2008年 / 15卷 / 18期

关键词：

antibacterial; antihelminthic; DNA-alkylation; intercalation; major- and minor-groove; transcription factor; polymerase; helicase; topoisomerase;

D O I：

10.2174/092986708785133013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B-12. Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and tris-benzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.

引用

页码：1762 / 1777

页数：16

共 162 条

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