Nrf2: A Potential Target for New Therapeutics in Liver Disease

被引：199

作者：

Bataille, A. M. ^{[1
]}

Manautou, J. E. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 92卷 / 03期

关键词：

TRANSCRIPTION FACTOR NRF2; ELEMENT-MEDIATED EXPRESSION; NF-KAPPA-B; OXIDATIVE STRESS; ACETAMINOPHEN HEPATOTOXICITY; BARDOXOLONE METHYL; ENZYME GENES; INDUCIBLE EXPRESSION; NRF2-KEAP1; PATHWAY; KIDNEY-FUNCTION;

D O I：

10.1038/clpt.2012.110

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nuclear erythroid 2-related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases-nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug-induced liver injury-and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression.

引用

页码：340 / 348

页数：9

共 75 条

[1] Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles [J].

Agyeman, Abena S. ;

Chaerkady, Raghothama ;

Shaw, Patrick G. ;

Davidson, Nancy E. ;

Visvanathan, Kala ;

Pandey, Akhilesh ;

Kensler, Thomas W. .

BREAST CANCER RESEARCH AND TREATMENT, 2012, 132 (01) :175-187

[2] Protective effects of allopurinol against acute liver damage and cirrhosis induced by carbon tetrachloride: Modulation of NF-κB, cytokine production and oxidative stress [J].

Aldaba-Muruato, Liseth R. ;

Moreno, Mario G. ;

Shibayama, Mineko ;

Tsutsumi, Victor ;

Muriel, Pablo .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (02) :65-75

[3] Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2 [J].

Aleksunes, Lauren M. ;

Slitt, Angela L. ;

Maher, Jonathan M. ;

Augustine, Lisa M. ;

Goedken, Michael J. ;

Chan, Jefferson Y. ;

Cherrington, Nathan J. ;

Klaassen, Curtis D. ;

Manautou, Jose E. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2008, 226 (01) :74-83

[4] Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease [J].

Aleksunes, Lauren M. ;

Manautou, Jose E. .

TOXICOLOGIC PATHOLOGY, 2007, 35 (04) :459-473

[5] Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity [J].

Aleksunes, Lauren M. ;

Goedken, Michael J. ;

Rockwell, Cheryl E. ;

Thomale, Juergen ;

Manautou, Jose E. ;

Klaassen, Curtis D. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 335 (01) :2-12

[6]

Arias I.M., 2009, The Liver Biology and Pathobiology, DOI 10.1002/9781119436812

[7] The cytoprotective role of the Keap1-Nrf2 pathway [J].

Baird, Liam ;

Dinkova-Kostova, Albena T. .

ARCHIVES OF TOXICOLOGY, 2011, 85 (04) :241-272

[8] Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease [J].

Bardag-Gorce, Fawzia ;

Oliva, Joan ;

Lin, Andrew ;

Li, Jun ;

French, Barbara A. ;

French, Samuel W. .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2011, 90 (01) :123-130

[9] Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it [J].

Begriche, K ;

Igoudjil, A ;

Pessayre, D ;

Fromenty, B .

MITOCHONDRION, 2006, 6 (01) :1-28

[10] Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein [J].

Chan, JY ;

Kwong, M .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2000, 1517 (01) :19-26

← 1 2 3 4 5 6 7 8 →