The 6-derivative of β-cyclodextrin with succinic acid:: a new chiral selector for CD-EKC

被引：32

作者：

Cucinotta, V ^{[1
]}

Giuffrida, A ^{[1
]}

Maccarrone, G ^{[1
]}

Messina, M ^{[1
]}

Puglisi, A ^{[1
]}

Torrisi, A ^{[1
]}

Vecchio, G ^{[1
]}

机构：

[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2005年 / 37卷 / 05期

关键词：

cyclodextrin; NMR; capillary electrophoresis; chiral separations; electrokinetic chromatography; catecholamines;

D O I：

10.1016/j.jpba.2004.08.023

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

6-O-Suceinil-beta-cyclodextrin (CDsuc6) was synthesized with very good yield by one pot synthesis and characterized by NMR spectroscopy and ESI-MS. It was used as a chiral selector in capillary electrophoresis to resolve catecholamine racemates, namely norepinephrine, epinephrine, terbutaline and norphenilephrine. The CE experiments at pH 5.6 show very promising selector ability by 6-O-succinil-beta-cyclodextrin for the chiral recognition of all the catecholamines tested, while at pH 9.2, only racemic terbutaline was successfully separated. (c) 2004 Elsevier B.V. All rights reserved.

引用

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页码：1009 / 1014

页数：6

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