Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity

被引：77

作者：

Harandi, AM

Svennerholm, B

Holmgren, J

Eriksson, K

机构：

[1] Gothenburg Univ, Dept Med Microbiol & Immunol, S-41346 Gothenburg, Sweden

[2] Gothenburg Univ, Dept Clin Virol, S-41346 Gothenburg, Sweden

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 14期

关键词：

D O I：

10.1128/JVI.75.14.6705-6709.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using a combination of gene-targeted mice and neutralizing antibodies, we showed that interleukin-12 (IL-12) and IL-18 are important in the innate control of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a protective gamma interferon-mediated immune response.

引用

收藏

页码：6705 / 6709

页数：5

相关论文

共 45 条

[1] In the absence of T cells, natural killer cells protect from mortality due to HSV-1 encephalitis [J].

Adler, H ;

Beland, JL ;

Del-Pan, NC ;

Kobzik, L ;

Sobel, RA ;

Rimm, IJ .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 93 (1-2) :208-213

[2] Differential susceptibility of several drug-resistant strains of herpes simplex virus type 2 to various antiviral compounds [J].

Andrei, G ;

Snoeck, R ;

DeClercq, E .

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1997, 8 (05) :457-461

[3]

Avice MN, 1998, J IMMUNOL, V161, P3408

[4]

Barbulescu K, 1998, J IMMUNOL, V160, P3642

[5]

Benencia F, 1999, IMMUNOLOGY, V98, P363

[6]

Cai GF, 1999, EUR J IMMUNOL, V29, P2658, DOI 10.1002/(SICI)1521-4141(199909)29:09<2658::AID-IMMU2658>3.0.CO

[7]

2-G

[8] Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii [J].

Cai, GF ;

Kastelein, R ;

Hunter, CA .

INFECTION AND IMMUNITY, 2000, 68 (12) :6932-6938

[9] Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro [J].

Carson, WE ;

Ross, ME ;

Baiocchi, RA ;

Marien, MJ ;

Boiani, N ;

Grabstein, K ;

Caligiuri, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2578-2582

[10] Humoral response to herpes simplex virus is complement-dependent [J].

Da Costa, XJ ;

Brockman, MA ;

Alicot, E ;

Ma, MH ;

Fischer, MB ;

Zhou, XN ;

Knipe, DM ;

Carroll, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12708-12712

← 1 2 3 4 5 →