TTF1-induced apoptosis of HepG-2 cells through a mitochondrial pathway

被引：30

作者：

Li, Yan ^{[1
]}

Bian, Lei ^{[1
]}

Cui, Fengde ^{[1
]}

Li, Liangchang ^{[1
]}

Zhang, Xuewu ^{[1
]}

机构：

[1] Yanbian Univ, Basic Med Coll, Yanji 133000, Jilin, Peoples R China

来源：

ONCOLOGY REPORTS | 2011年 / 26卷 / 03期

关键词：

Sorbaria sorbifolia; 5,2 ',4 '-trihydroxy-6,7; 5 '-trimethoxyflavone; apoptosis; SIGNALING PATHWAY; HUMAN LEUKEMIA; DEATH PATHWAY; ACTIVATION; RELEASE;

D O I：

10.3892/or.2011.1330

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The Chinese medicinal herb Sorbaria sorbifolia, native to Changbai Mountain, can induce apoptosis in HepG-2 cells. We studied the mechanism by which 5, 2',4'-trihydroxy-6,7, 5'-trimethoxyflavone (TTF1) isolated from acetic ether extracts of Sorbaria sorbifolia induces apoptosis in HepG-2 cells. The results showed that TTF1 both inhibited cell growth and induced apoptosis. RT-PCR and Western blot analysis showed that TTF1 treatment led to decreased transcription and protein expression of bcl-2 and an increase in bax, Cyt-c, caspase-3 and caspase-9. These results together suggest that TTF1 may induce apoptosis of HepG-2 cells through a mitochondrial pathway.

引用

收藏

页码：651 / 657

页数：7

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