SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

被引：41

作者：

Appendino, G

Prosperini, S

Valdivia, C

Ballero, M

Colombano, G

Billington, RA

Genazzani, AA

Sterner, O

机构：

[1] Univ Piemonte Orientale, Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

[2] Consorzio Studio Metab Secondari, I-09123 Cagliari, Italy

[3] Lund Univ, Dept Organ Chem, S-22100 Lund, Sweden

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 08期

关键词：

D O I：

10.1021/np050115m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

引用

页码：1213 / 1217

页数：5

共 13 条

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[2] COMPARISON OF CA-2+ MOBILIZING ACTIVITIES OF CYCLIC ADP-RIBOSE AND INOSITOL TRISPHOSPHATE [J].