Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation

被引：70

作者：

Choi, Jae Yong ^{[1
,2
]}

Cho, Hanna ^{[3
]}

Ahn, Sung Jun ^{[4
]}

Lee, Jae Hoon ^{[1
]}

Ryu, Young Hoon ^{[1
]}

Lee, Myung Sik ^{[3
]}

Lyoo, Chul Hyoung ^{[3
]}

机构：

[1] Yonsei Univ, Gangnam Severance Hosp, Dept Nucl Med, Coll Med, 20 Eonjuro 63 Gil, Seoul, South Korea

[2] Korea Inst Radiol & Med Sci, Div Rhode Isl Convergence Res, Seoul, South Korea

[3] Yonsei Univ, Gangnam Severance Hosp, Dept Neurol, Coll Med, 20 Eonjuro 63 Gil, Seoul, South Korea

[4] Yonsei Univ, Gangnam Severance Hosp, Dept Radiol, Coll Med, Seoul, South Korea

来源：

JOURNAL OF NUCLEAR MEDICINE | 2018年 / 59卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

F-18-AV-1451; PET; iron; aging; basal ganglia; PROGRESSIVE SUPRANUCLEAR PALSY; POSITRON-EMISSION-TOMOGRAPHY; HUMAN BRAIN; ALZHEIMERS-DISEASE; POSTMORTEM;

D O I：

10.2967/jnumed.117.195248

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Off-target binding in the basal ganglia is commonly observed in the F-18-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R*(2) MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent F-18-AV-1451 PET and R*(2) MRI studies. A correlation analysis was performed for age, F-18-AV-1451 binding, and R*(2) values. Results: There was an age-related increase in both F-18-AV-1451 binding in the basal ganglia and R*(2) values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. F-18-AV-1451 binding in the basal ganglia increased with R*(2) values. Conclusion: Off-target F-18-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

引用

页码：117 / 120

页数：4

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