Antipsychotics in children and adolescents

被引:64
作者
Campbell, M
Rapoport, JL
Simpson, GM
机构
[1] NYU, Med Ctr, Dept Psychiat, New York, NY 10016 USA
[2] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA
[3] Univ So Calif, Dept Psychiat & Behav Sci, Los Angeles, CA USA
关键词
antipsychotics; efficacy; safety; review;
D O I
10.1097/00004583-199905000-00015
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 [发展与教育心理学];
摘要
Objectives: To present a critical overview of the available evidence for the efficacy and safety of antipsychotic agents in children and adolescents and to identify knowledge gaps and needs for further research. Data from adults that are relevant to children are discussed. Method: Mainly reports of double-blind, placebo-controlled studies were reviewed. Results: In children and adolescents, antipsychotics are used to treat psychotic and a variety of nonpsychotic conditions. The amount of data based on well-designed, double-blind, placebo-controlled studies with satisfactory sample sizes in diagnostically homogeneous subjects is modest. Conclusions: Currently available standard antipsychotics have a definite role in the treatment of children and adolescents. The use of these agents is limited mainly by tardive and withdrawal dyskinesias and, in same patients, by excessive sedation. The atypical antipsychotics should be critically assessed and compared with psychosocial interventions; it effective, the combination of both types of treatments should be evaluated.
引用
收藏
页码:537 / 545
页数:9
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