cGMP signalling beyond nitric oxide

被引：27

作者：

Mayer, B

Koesling, D

机构：

[1] Karl Franzens Univ Graz, Inst Pharmakol & Toxikol, A-8010 Graz, Austria

[2] Ruhr Univ Bochum, Inst Pharmakol & Toxikol, D-44780 Bochum, Germany

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2001年 / 22卷 / 11期

关键词：

D O I：

10.1016/S0165-6147(00)01889-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Many of the physiological effects of nitric oxide are mediated by activation of soluble guanylyl cyclase, resulting in cellular cGMP accumulation. In the 1990s, the benzylindazole derivative YC-1 was identified as a novel modulator of cGMP signalling that exerted complex actions in a NO-independent manner. A recent study describes a high-affinity YC-1 analogue that decreases blood pressure in hypertensive rats and increases bleeding time, which suggests that this drug might have therapeutic potential as a vasodilator with antiplatelet activity.

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收藏

页码：546 / 548

页数：3

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