cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor

被引：17

作者：

Devilder, MC ^{[1
]}

Cadoret, E ^{[1
]}

Chérel, M ^{[1
]}

Moreau, I ^{[1
]}

Rondeau, G ^{[1
]}

Bézieau, S ^{[1
]}

Moisan, JP ^{[1
]}

机构：

[1] CHU Nantes, Hotel Dieu, Inst Biol, INSERM U463, F-44093 Nantes, France

来源：

GENOMICS | 1998年 / 54卷 / 01期

关键词：

D O I：

10.1006/geno.1998.5498

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report the characterization of a new gene mapped at chromosome band 13q14.3 telomeric to the retinoblastoma gene. This gene, designated CHC1L (for chromosome condensation 1-like), is composed of 14 exons spanning 30 kb of genomic DNA and encodes a ubiquitously expressed 3-kb mRNA. The N-terminal half of the deduced amino acid sequence shows strong homology with the seven tandem repeat structure of the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. CHC1L appears to be a new member of the RCC1-related GEF family, (C) 1998 Academic Press.

引用

页码：99 / 106

页数：8

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