Catalytic synthesis of γ-lactams via direct annulations of enals and N-sulfonylimines

被引：271

作者：

He, M ^{[1
]}

Bode, JW ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93101 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 14期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/ol051234w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cinnamaldehydes and N-sulfonylimines undergo direct annulations to cis-disubstituted gamma-lactams via the intermediacy of catalytically generated homoenolates. Critical to the success of this process was overcoming inhibition of the N-heterocyclic carbene catalyst by the electrophilic imines. The overall process proceeds with good yields and diastereoselectivites and requires no stoichiometric reagents or additives.

引用

页码：3131 / 3134

页数：4

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