Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi

被引：25

作者：

Kim, DW

Bang, KH

Rhee, YH

Lee, KT

Park, HJ ^{[1
]}

机构：

[1] Sangji Univ, Dept Bot Resources, Wonju 220702, South Korea

[2] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku, Sugitani, Toyama 93001, Japan

[3] Chungnam Natl Univ, Dept Microbiol, Taejon 305764, South Korea

[4] Kyung Hee Univ, Coll Pharm, Dongdaemun Ku, Seoul 130701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 06期

关键词：

kalopanaxsaponin; antifungal activities; minimum inhibitory concentration (MIC); dermatomycosis;

D O I：

10.1007/BF02976758

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antifungal activities of the compounds isolated from Kalopanax pictus against representative fungi of dermatomycosis were investigated using paper disc diffusion method. It was found that kalopanaxsaponins A and I were effective in inhibiting the growth of Candida albicans KCTC 1940 and Cryptococcus neoformans KCTC 7224 with minimum inhibitory concentration (MIC) of 25 mu g/ml. it showed that antifungal activity of both compounds have strong selectivity against the fungi of dermatomycosis.

引用

页码：688 / 691

页数：4

共 17 条

[1] STRUCTURES OF THE 4 AVENACINS, OAT ROOT RESISTANCE FACTORS TO TAKE-ALL DISEASE [J].