Reversing dobutamine-induced tachycardia using ivabradine increases stroke volume with neutral effect on cardiac energetics in left ventricular post-ischaemia dysfunction

AimCompensatory tachycardia can potentially be deleterious in acute heart failure. In this study, we tested a therapeutic strategy of combined inotropic support (dobutamine) and selective heart rate (HR) reduction through administration of ivabradine. MethodsIn an open-chest pig model (n=12) with left ventricular (LV) post-ischaemia dysfunction, cardiac function was assessed by LV pressure catheter and sonometric crystals. Coronary flow and blood samples from the coronary sinus were used to measure myocardial oxygen consumption (MVO2). LV energetics was assessed by comparing MVO2 with cardiac work at a wide range of workloads. ResultsIn the post-ischaemia heart, dobutamine (5g kg(-1)min(-1)) increased cardiac output (CO) by increasing HR from 10221 to 131 +/- 16bpm (beats per min; P<0.05). Adding ivabradine (0.5mgkg(-1)) slowed HR back to 100 +/- 9bpm and increased stroke volume from 30 +/- 5 to 36 +/- 5mL (P<0.05) by prolonging diastolic filling time and increasing end-diastolic dimensions. Adding ivabradine had no adverse effects on CO, mean arterial pressure and cardiac efficiency. Similar findings on efficiency and LV function were also seen using an exvivo working mouse heart protocol. ConclusionsA combined infusion of dobutamine and ivabradine had a neutral effect on post-ischaemia LV efficiency and increased left ventricular output without an increase in HR.