Preparation and study on the novel solid inclusion complex of ciprofloxacin with HP-β-cyclodextrin

被引：41

作者：

Chao, JB ^{[1
]}

Meng, DP ^{[1
]}

Li, JS ^{[1
]}

Xu, H ^{[1
]}

Huang, SP ^{[1
]}

机构：

[1] Shanxi Univ, Test & Anal Ctr, TaiYuan 030006, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2004年 / 60卷 / 03期

关键词：

ciprofloxacin; HP-beta-CD; inclusion complex; 1D NMR; 2D NMR;

D O I：

10.1016/S1386-1425(03)00284-1

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The interaction of ciprofloxacin with HP-beta-cyclodextrin (HP-beta-CD) has been studied by several analytical techniques, including H-1 nuclear magnetic resonance (NMR), C-13 NMR, fluorescence spectra, infrared spectroscopy, thermal analyzer and scanning electron microscope. In this paper, solid inclusion complex of ciprofloxacin with HP-beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, infrared, differential scanning calorimetry and one-dimensional (1D), 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of ciprofloxacin with HP-beta-CD. The formation constant of complex was determined by fluorescence method and H-1 NMR. Spacial configuration of complex has been proposed on two-dimensional NMR technique. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：729 / 734

页数：6

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