Automated radiosynthesis of [18F]PBR111 and [18F]PBR102 using the Tracerlab FXFN and Tracerlab MXFDG module for imaging the peripheral benzodiazepine receptor with PET

被引：18

作者：

Bourdier, Thomas ^{[1
]}

Pham, Tien Q. ^{[2
]}

Henderson, David ^{[1
]}

Jackson, Timothy ^{[2
]}

Lam, Peter ^{[1
]}

Izard, Michael ^{[2
]}

Katsifis, Andrew ^{[2
]}

机构：

[1] Royal Prince Alfred Hosp, PET & Nucl Med Dept, Camperdown, NSW 2050, Australia

[2] Australian Nucl Sci & Technol Org, LifeSci, Sydney, NSW 2232, Australia

来源：

APPLIED RADIATION AND ISOTOPES | 2012年 / 70卷 / 01期

关键词：

F-18]PBR111; F-18]PBR102; F-18]fluorination; Tracerlab FXFN; Tracerlab MXFDG; BINDING-SITES; AUTORADIOGRAPHIC LOCALIZATION; MICROGLIAL ACTIVATION; MULTIPLE-SCLEROSIS; IN-VIVO; DISEASE; BRAIN; PARKINSONS;

D O I：

10.1016/j.apradiso.2011.07.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

[F-18]PBR111 and [F-18]PBR102 are selective radioligands for imaging of the Peripheral Benzodiazepine Receptor (PBR). We have developed a fully automated method for the radiosynthesis of [F-18]PBR111 and [F-18]PBR102 in the Tracerlab FXFN (30 +/- 2% radiochemical yield non-decay-corrected for both tracers) and Tracerlab MXFDG (25 +/- 2% radiochemical yield non-decay-corrected for both tracers) from the corresponding p-toluenesulfonyl precursors. For all tracers, radiochemical purity was > 99% and specific activity was > 150 GBq/mu mol after less than 60 min of preparation time. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：176 / 183

页数：8

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