Influence of renal failure on intestinal clearance of ciprofloxacin in rats

被引：9

作者：

Dautrey, S

Rabbaa, L

Laouari, D

Lacour, B

Carbon, C

Farinotti, R

机构：

[1] GH Bichat C Bernard, Serv Pharm Clin & Biomat, F-75018 Paris, France

[2] GH Bichat C Bernard, INSERM, U426, F-75018 Paris, France

[3] Univ Paris 11, Fac Pharm, Lab Pharm Clin, F-92290 Chatenay Malabry, France

[4] GH Bichat C Bernard, Serv Pharm Clin & Biomat, F-75018 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 03期

关键词：

D O I：

10.1128/AAC.43.3.678

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Following intravenous doses, ciprofloxacin pharmacokinetics in control and nephrectomized rats were studied. There were no differences between control and nephrectomized rats for area under the concentration-time curve in plasma or biliary clearance. The intestinal clearance of ciprofloxacin was increased in nephrectomized rats. Intestinal elimination seems to compensate partially fur the decrease in urinary excretion of ciprofloxacin in nephrectomized rats.

引用

页码：678 / 680

页数：3

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