Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics

被引：13

作者：

Granzow, M

Popp, S

Weber, S

Schoell, B

Holtgreve-Grez, H

Senf, L

Hager, D

Boschert, J

Scheurlen, W

Jauch, A

机构：

[1] Univ Heidelberg, Inst Human Genet, D-69120 Heidelberg, Germany

[2] Deutsch Krebsforschungszentrum, Div Genet Skin Carcinogenesis, D-69120 Heidelberg, Germany

[3] Univ Heidelberg, Fac Clin Med Mannheim, Dept Neurosurg, D-68167 Mannheim, Germany

[4] Univ Heidelberg, Fac Clin Med Mannheim, Childrens Hosp, D-68167 Mannheim, Germany

来源：

CANCER GENETICS AND CYTOGENETICS | 2001年 / 130卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(01)00465-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Data concerning cytogenetic features of childhood ependymoma are rare. In this article, a gain of 1q was identified as the sole alteration in a primary childhood infratentorial ependymoma by comparative genomic hybridization (CGH). A recurrence of this brain tumor was studied using multiplex-fluorescence in situ hybridization (M-FISH) in addition to CGH and G-banding analysis. In accordance with the primary tumor, a gain of Iq corresponding to an isochromosome Iq was observed indicating an early event in the tumor development. Furthermore, M-FISH classified several other rearranged chromosomes including 6q and 17p that have previously been found to be involved in the development and progression of childhood ependymoma. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：79 / 83

页数：5

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