Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery

被引：8

作者：

Hidai, C

Kawana, M

Habu, K

Kazama, H

Kawase, Y

Iwata, T

Suzuki, H

Quertermous, T

Kokubun, S

机构：

[1] Nihon Univ, Sch Med, Dept Physiol, Res Ctr Adv Med,Itabashi Ku, Tokyo 1628666, Japan

[2] Tokyo Womens Med Univ, Aoyama Hosp, Tokyo, Japan

[3] Chugai Pharmaceut Co Ltd, Pharmaceut Technol Lab, Shizuoka, Japan

[4] Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA

来源：

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY | 2005年 / 287A卷 / 02期

关键词：

branching morphogenesis; angiogenesis; mesentery; Del1; SDF-1;

D O I：

10.1002/ar.a.20247

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery. (c) 2005 Wiley-Liss, Inc.

引用

页码：1165 / 1175

页数：11

共 31 条

[1] Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis [J].