Advances in Development of New Treatment for Leishmaniasis

被引：138

作者：

Bezerra de Menezes, Juliana Perrone ^{[1
]}

Sampaio Guedes, Carlos Eduardo ^{[1
]}

de Oliveira Almeida Petersen, Antonio Luis ^{[1
]}

Mothe Fraga, Deborah Bittencourt ^{[1
]}

Tavares Veras, Patricia Sampaio ^{[1
]}

机构：

[1] Fiocruz MS, CPqGM, Lab Patol & Biointervencao, BR-40296710 Salvador, BA, Brazil

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

LIPOSOMAL AMPHOTERICIN-B; HEAT-SHOCK-PROTEIN; DIFFERENTIALLY EXPRESSED PROTEINS; PROTOZOAN PARASITE LEISHMANIA; PLASMODIUM-FALCIPARUM GROWTH; ABC-TRANSPORTER MRPA; VISCERAL LEISHMANIASIS; PROTEOMIC ANALYSIS; CUTANEOUS LEISHMANIASIS; GENE-EXPRESSION;

D O I：

10.1155/2015/815023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Leishmaniasis is a neglected infectious disease caused by several different species of protozoan parasites of the genus Leishmania. Current strategies to control this disease are mainly based on chemotherapy. Despite being available for the last 70 years, leishmanial chemotherapy has lack of efficiency, since its route of administration is difficult and it can cause serious side effects, which results in the emergence of resistant cases. The medical-scientific community is facing difficulties to overcome these problems with new suitable and efficient drugs, as well as the identification of new drug targets. The availability of the complete genome sequence of Leishmania has given the scientific community the possibility of large-scale analysis, which may lead to better understanding of parasite biology and consequent identification of novel drug targets. In this review we focus on how high-throughput analysis is helping us and other groups to identify novel targets for chemotherapeutic interventions. We further discuss recent data produced by our group regarding the use of the high-throughput techniques and how this helped us to identify and assess the potential of new identified targets.

引用

页数：11

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