Color changing photonic crystals detect blast exposure

被引:18
作者
Cullen, D. Kacy [1 ]
Xu, Yongan [2 ]
Reneer, Dexter V. [3 ]
Browne, Kevin D. [1 ]
Geddes, James W. [3 ]
Yang, Shu [2 ]
Smith, Douglas H. [1 ]
机构
[1] Univ Penn, Dept Neurosurg, Sch Med, Ctr Brain Injury & Repair, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Mat Sci & Engn, Sch Engn & Appl Sci, Philadelphia, PA 19104 USA
[3] Univ Kentucky, Coll Med,Dept Anat & Neurobiol, Albert B Chandler Med Ctr, Spinal Cord & Brain Injury Res Ctr, Lexington, KY 40536 USA
基金
美国国家卫生研究院;
关键词
TRAUMATIC BRAIN-INJURY; HEAD-INJURY; MULTIBEAM INTERFERENCE; RECURRENT CONCUSSION; ALZHEIMERS-DISEASE; AFGHANISTAN; FABRICATION; FREQUENCY; DEMENTIA; ONSET;
D O I
10.1016/j.neuroimage.2010.10.076
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Blast-induced traumatic brain injury (bTBI) is the "signaturewound" of the current wars in Iraq and Afghanistan. However, with no objective information of relative blast exposure, warfighters with bTBI may not receive appropriate medical care and are at risk of being returned to the battlefield. Accordingly, we have created a colorimetric blast injury dosimeter (BID) that exploits material failure of photonic crystals to detect blast exposure. Appearing like a colored sticker, the BID is fabricated in photosensitive polymers via multi-beam interference lithography. Although very stable in the presence of heat, cold or physical impact, sculpted micro -and nano-structures of the BID are physically altered in a precise manner by blast exposure, resulting in color changes that correspond with blast intensity. This approach offers a lightweight, power-free sensor that can be readily interpreted by the naked eye. Importantly, with future refinement this technology may be deployed to identify soldiers exposed to blast at levels suggested to be supra-threshold for non-impact blast-induced mild TBI. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:S37 / S44
页数:8
相关论文
共 37 条
  • [1] Bauman RA, 2009, J NEUROTRAUM, V26, P841, DOI [10.1089/neu.2008.0898, 10.1089/neu.2009-0898]
  • [2] Fabrication of photonic crystals for the visible spectrum by holographic lithography
    Campbell, M
    Sharp, DN
    Harrison, MT
    Denning, RG
    Turberfield, AJ
    [J]. NATURE, 2000, 404 (6773) : 53 - 56
  • [3] Recurrent athletic head injury: risks and when to retire
    Cantu, RC
    [J]. CLINICS IN SPORTS MEDICINE, 2003, 22 (03) : 593 - +
  • [4] Ultrastructural and functional characteristics of blast injury-induced neurotrauma
    Cernak, I
    Wang, ZG
    Jiang, JX
    Bian, XW
    Savic, J
    [J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2001, 50 (04): : 695 - 706
  • [5] Neuropsychology of sports-related head injury: Dementia Pugilistica to Post Concussion Syndrome
    Erlanger, DM
    Kutner, KC
    Barth, JT
    Barnes, R
    [J]. CLINICAL NEUROPSYCHOLOGIST, 1999, 13 (02) : 193 - 209
  • [6] Head injury and the risk of AD in the MIRAGE study
    Guo, Z
    Cupples, LA
    Kurz, A
    Auerbach, SH
    Volicer, L
    Chui, H
    Green, RC
    Sadovnick, AD
    Duara, R
    DeCarli, C
    Johnson, K
    Go, RC
    Growdon, JH
    Haines, JL
    Kukull, WA
    Farrer, LA
    [J]. NEUROLOGY, 2000, 54 (06) : 1316 - 1323
  • [7] Association between recurrent concussion and late-life cognitive impairment in retired professional football players
    Guskiewicz, KM
    Marshall, SW
    Bailes, J
    McCrea, M
    Cantu, RC
    Randolph, C
    Jordan, BD
    [J]. NEUROSURGERY, 2005, 57 (04) : 719 - 724
  • [8] Cumulative effects associated with recurrent concussion in collegiate football players - The NCAA Concussion Study
    Guskiewicz, KM
    McCrea, M
    Marshall, SW
    Cantu, RC
    Randolph, C
    Barr, W
    Onate, JA
    Kelly, JP
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (19): : 2549 - 2555
  • [9] Mild traumatic brain injury in US Soldiers returning from Iraq
    Hoge, Charles W.
    McGurk, Dennis
    Thomas, Jeffrey L.
    Cox, Anthony L.
    Engel, Charles C.
    Castro, Carl A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (05) : 453 - 463
  • [10] Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's disease
    Jellinger, KA
    Paulus, W
    Wrocklage, C
    Litvan, I
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2001, 8 (06) : 707 - 710