The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research

被引：98

作者：

Berry, Donald A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Div Quantitat Sci, Houston, TX USA

来源：

MOLECULAR ONCOLOGY | 2015年 / 9卷 / 05期

关键词：

Biomarker-driven clinical trials; Platform trials; Basket trials; Bayesian adaptive clinical trials; PERSONALIZED MEDICINE; LUNG-CANCER; FREE SURVIVAL; BATTLE TRIAL; THERAPY; DESIGN;

D O I：

10.1016/j.molonc.2015.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platform trials and basket trials. Both are attempting to merge clinical research and clinical practice. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：951 / 959

页数：9

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