The costimulatory molecule ICOS plays an important role in immunopathogenesis of EAE

被引：236

作者：

Rottman, JB ^{[1
]}

Smith, T ^{[1
]}

Tonra, JR ^{[1
]}

Ganley, K ^{[1
]}

Bloom, T ^{[1
]}

Silva, R ^{[1
]}

Pierce, B ^{[1
]}

Gutierrez-Ramos, JC ^{[1
]}

Özkaynak, E ^{[1
]}

Coyle, AJ ^{[1
]}

机构：

[1] Millennium Pharmaceut, Cambridge, MA 02139 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 07期

关键词：

D O I：

10.1038/89750

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inducible costimulatory molecule (ICOS) is expressed on activated T cells and participates in a variety of important immunoregulatory functions. After the induction of experimental allergic encephalomyelitis in SJL mice with proteolipid protein (PLP), brain ICOS mRNA and protein were up-regulated on infiltrating CD3(+) T cells before disease onset. ICOS blockade during the efferent immune response (9-20 days after immunization) abrogated disease, but blockade during antigen priming (1-10 days after immunization) exacerbated disease. Upon culture with PLP and compared with immunized controls, splenocytes produced either decreased interferon-gamma (IFN-gamma, in efferent blockade) or excessive IFN-gamma (in priming blockade). PLP-specific immunoglobulin GI was decreased in animals treated with anti-ICOS during antigen priming, but not in other groups.

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页码：605 / 611

页数：7

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