In vitro models of age-related neurodegenerative disorders

被引：8

作者：

Delacourte, A ^{[1
]}

Sergeant, N ^{[1
]}

Buée, L ^{[1
]}

机构：

[1] INSERM, U422, Inst Med Predict & Rech Therapeut, F-59045 Lille, France

来源：

EXPERIMENTAL GERONTOLOGY | 2003年 / 38卷 / 11-12期

关键词：

alzheimer's disease; neurodegenerative disorder; aging;

D O I：

10.1016/j.exger.2003.09.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is the major risk factor for numerous brain diseases. This is especially true for Alzheimer's disease (AD), a peculiar neurodegenerative disorder in that it results from the synergy of two simultaneous but distinct degenerating processes: Abeta and tau pathologies. For AD, and for most neurodegenerative disorders, aggregation of full length or truncated proteins, in neurons or glial cells, or in the parenchyma, is central, but still a mystery. In addition, the late onset of these pathologies links them to ageing processes. Cause or consequence? Experimental models, that allow us to dissect these pathophysiological defects, are presented. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1309 / 1317

页数：9

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