Sputum and BAL Clara cell secretory protein and surfactant protein D levels in asthma

被引：25

作者：

Emmanouil, P. ^{[1
]}

Loukides, S. ^{[2
]}

Kostikas, K. ^{[2
]}

Papatheodorou, G. ^{[3
]}

Papaporfyriou, A. ^{[1
]}

Hillas, G. ^{[1
]}

Vamvakaris, I. ^{[4
]}

Triggidou, R. ^{[4
]}

Katafigiotis, P. ^{[4
]}

Kokkini, A. ^{[5
]}

Papiris, S. ^{[2
]}

Koulouris, N. ^{[1
]}

Bakakos, P. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Resp Med 1, Sotiria Hosp Chest Dis, Athens 11634, Greece

[2] Univ Athens, Sch Med, Dept Resp Med 1, Attikon Hosp, Athens 11634, Greece

[3] 401 Gen Army Hosp, Res Unit, Athens, Greece

[4] Sotiria Hosp Chest Dis, Dept Pathol, Athens, Greece

[5] Sotiria Hosp Chest Dis, Cytol Dept, Athens, Greece

来源：

ALLERGY | 2015年 / 70卷 / 06期

关键词：

asthma; clinical immunology; remodelling;

D O I：

10.1111/all.12603

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Clara cell secretory protein (CC16) is associated with Th2 modulation. Surfactant protein D (SPD) plays an important role in surfactant homeostasis and eosinophil chemotaxis. We measured CC16 and SPD in sputum supernatants of 84 asthmatic patients and 12 healthy controls. In 22 asthmatics, we additionally measured CC16 and SPD levels in BAL and assessed smooth muscle area (SMA), reticular basement membrane (RBM) thickness, and epithelial detachment (ED) in bronchial biopsies. Induced sputum CC16 and SPD were significantly higher in patients with severe asthma (SRA) compared to mild-moderate and healthy controls. BAL CC16 and SPD levels were also higher in SRA compared to mild-moderate asthma. CC16 BAL levels correlated with ED, while SPD BAL levels correlated with SMA and RBM. Severity represented a significant covariate for these associations. CC16 and SPD levels are upregulated in SRA and correlate with remodeling indices, suggesting a possible role of these biomarkers in the remodeling process.

引用

页码：711 / 714

页数：4

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