NIR spectrometry for counterfeit drug detection - A feasibility study

被引：130

作者：

Rodionova, OY

Houmoller, LP

Pomerantsev, AL

Geladi, P

Burger, J

Dorofeyev, VL

Arzamastsev, AP

机构：

[1] Semenov Inst Chem Phys, Moscow 119991, Russia

[2] Aalborg Univ, Esbjerg, Denmark

[3] Swedish Univ Agr Sci, Unit Biomass Technol & Chem, S-90183 Umea, Sweden

[4] Sechenov Moscow Med Acad, Moscow, Russia

来源：

ANALYTICA CHIMICA ACTA | 2005年 / 549卷 / 1-2期

关键词：

counterfeit drugs; near infra-red spectrometry; hyperspectral image analysis; multivariate classification;

D O I：

10.1016/j.aca.2005.06.018

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Express-methods for detection of counterfeit drugs are of vital necessity. Visual control, dissociating tests or simple color reaction tests reveal only very rough forgeries. The feasibility of information-rich NIR-measurements as an analytical method together with multivariate calibration for mathematical data processing for false drugs detection is demonstrated. Also, multivariate hyperspectral image analysis is applied providing additional diagnostic information. Hyperspectral imaging is becoming a useful diagnostic tool for identifying non-homogeneous spatial regions of drug formulation. Two types of drugs are used to demonstrate the applicability of these approaches. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：151 / 158

页数：8

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