Inspired porosity for cells and tissues

The use of 3D scaffolds provides an adhesive substrate that become the physical support matrix for in vivo tissue regeneration. In the last few years the use of bioengineered 3D scaffolds is becoming the most promising experimental approach for the regeneration of living tissue. Stem cells are used to study the signaling pathways that mediate cell differentiation and to identify optimal microenvironments that support cellular functionality. For tissue engineering applications 3D biomaterials must be able of supporting the functional properties of osteogenic cells. Inorganic devices are particularly relevant for bone regeneration; in particular calcium phosphate ceramics have been shown to interact strongly particularly with bone. The aim of the present work was the design and the production of a 3D Calcium/Phosphate scaffold able to mimics the in vivo environment to induce/promote tissue repair; the scaffold developed shows a defined design able to achieve the required functionality.