Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization

被引：43

作者：

Erez, Neta ^{[3
]}

Coussens, Lisa M. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

[3] Tel Aviv Univ, Sackler Sch Med, Dept Pathol, IL-69978 Tel Aviv, Israel

来源：

INTERNATIONAL JOURNAL OF CANCER | 2011年 / 128卷 / 11期

关键词：

leukocytes; inflammation; cancer; metastasis; TUMOR-ASSOCIATED MACROPHAGES; GR-1+CD11B+ MYELOID CELLS; BREAST-CANCER METASTASIS; B PROMOTES PROGRESSION; LYMPH-NODE METASTASIS; NF-KAPPA-B; LUNG METASTASIS; MATRIX METALLOPROTEINASES; CATHEPSIN-B; CHEMOKINE RECEPTORS;

D O I：

10.1002/ijc.26032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

It is now well recognized that tumor cell-host interactions regulate all aspects of cancer development. Amongst the various host response programs that facilitate primary cancer development, an emerging body of literature points to a critical role for leukocytes and their soluble mediators as regulating discrete events during primary tumor development and metastasis. This review focuses on the multiple aspects of leukocytes and their effector molecules as regulators of the metastatic process.

引用

页码：2536 / 2544

页数：9

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