Ferrohydrodynamic relaxometry for magnetic particle imaging

被引：83

作者：

Goodwill, P. W. ^{[1
]}

Tamrazian, A. ^{[1
]}

Croft, L. R. ^{[1
]}

Lu, C. D. ^{[1
]}

Johnson, E. M. ^{[1
]}

Pidaparthi, R. ^{[1
]}

Ferguson, R. M. ^{[2
]}

Khandhar, A. P. ^{[2
]}

Krishnan, K. M. ^{[2
]}

Conolly, S. M. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[2] Univ Washington, Seattle, WA 98195 USA

来源：

APPLIED PHYSICS LETTERS | 2011年 / 98卷 / 26期

关键词：

D O I：

10.1063/1.3604009

中图分类号：

O59 [应用物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The ferrohydrodynamic properties of magnetic nanoparticles govern resolution and signal strength in magnetic particle imaging (MPI), a medical imaging modality with applications in small animals and humans. Here, we discuss the development and key results of a magnetic particle relaxometer that measures the core diameter and relaxation constant of magnetic nanoparticles. This instrument enables us to directly measure the one-dimensional MPI point spread function. To elucidate our results, we develop a simplified ferrohydrodynamic model that assumes nanoparticles respond to time varying magnetic fields according to a Debeye model of Brownian relaxation, which we verify with experimental data. (C) 2011 American Institute of Physics. [doi:10.1063/1.3604009]

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