Hydroxyapatite-collagen-hyaluronic acid composite

被引：121

作者：

Bakos, D

Soldán, M

Hernández-Fuentes, I

机构：

[1] Slovak Univ Technol Bratislava, Fac Chem Technol, Bratislava 81237, Slovakia

[2] Univ Complutense, Fac Chem Sci, Madrid, Spain

来源：

BIOMATERIALS | 1999年 / 20卷 / 02期

关键词：

hydroxyapatite; collagen; hyaluronic acid; composite implants;

D O I：

10.1016/S0142-9612(98)00163-X

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The new composite biomaterial made from hydroxyapatite and collagen conjugated with hyaluronic acid has been studied. The structure evaluation of the composite showed more dense arrangement due to the formation of collagen-hyaluronic acid conjugate, and particles of inorganic component are closely anchored in the structure. Mechanical properties and model swelling of this composite are compared with properties of hydroxyapatite-collagen composite of similar material without hyaluronic acid. Higher cohesivity of the new biomaterial can give new possibilities for application as bone implant material. The test of contact cytotoxicity showed a very good biocompatibility of the biomaterial. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：191 / 195

页数：5

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