Split-split. A multiple synthesiser approach to efficient automated parallel synthesis

被引：17

作者：

Brooking, P ^{[1
]}

Doran, A ^{[1
]}

Grimsey, P ^{[1
]}

Hird, NW ^{[1
]}

MacLachlan, WS ^{[1
]}

Vimal, M ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AD, Essex, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(98)02620-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A multiple synthesiser approach to high efficiency, high throughput synthesis is described. It involves eliminating duplication in multi-step synthesis by establishing a cascade of matched synthesisers in which each machine performs a single step and provides feedstocks for the next instrument. The utility of this approach is illustrated by the efficient construction of a large array by a 4 step solution synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1405 / 1408

页数：4

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