MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among US men and women: An example of gene-environment interactions in colorectal tumorigenesis

被引：99

作者：

Chen, J ^{[1
]}

Giovannucci, EL

Hunter, DJ

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Harvard Ctr Canc Prevent, Boston, MA 02115 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Channing Lab, Boston, MA 02115 USA

来源：

JOURNAL OF NUTRITION | 1999年 / 129卷 / 02期

关键词：

MTHFR polymorphism; colorectal cancer; colorectal adenomas; methyl diet;

D O I：

10.1093/jn/129.2.560S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Our studies on interactions of a folate-metabolizing gene polymorphism and dietary intake in colorectal tumorigenesis demonstrate the potential importance of studying interactions between genotype and environmental exposure in relation to cancer risk. We observed an inverse association of a polymorphism (667C --> T, ala --> val) in the methylenetetrahydrofolate reductase (MTHFR) gene with colorectal cancer but not with colorectal adenomas. The inverse association of methionine and adverse association of alcohol with colorectal cancer were stronger among val/val individuals. These interactions were not present in studies of colorectal adenomas, Our studies illustrate that studying gene-environment interactions in relation to cancer can be of importance in clarifying cancer etiology as well as pointing to preventive dietary modifications.

引用

页码：560S / 564S

页数：5

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