A new method for imaging perfusion and contrast extraction fraction: Input functions derived from reference tissues

被引:125
作者
Kovar, DA [1 ]
Lewis, M [1 ]
Karczmar, GS [1 ]
机构
[1] Univ Chicago, Med Ctr, Dept Radiol, Chicago, IL 60637 USA
关键词
MRI; capillary permeability; perfusion; contrast agent;
D O I
10.1002/jmri.1880080519
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This study describes a new method for analysis of dynamic MR contrast data that greatly increases the time available for data acquisition. The capillary input function, CB(t), is estimated from the rate of contrast agent uptake in a reference tissue such as muscle, based on literature values for perfusion rate, extraction fraction, and extracellular volume. The rate constant for contrast uptake (the product of perfusion rate, F, and extraction fraction, E; F.E) is then determined in each image pixel using CB(t), extracellular volume (relative to the reference tissue) measured from MR and the tissue concentration of contrast media as a function of time calculated from the MR data, The "reference tissue method" was tested using rats with mammary (n = 10) or prostate (n = 15) tumors implanted in the hindlimb, Dynamic MR images at 4.7 T were acquired before and after Gd-DTPA intravenous bolus injections to determine F.EGd-DTPA. Acquisition parameters were optimized for detection of the first pass of the contrast agent bolus, so that "first-pass analysis" could be used as the "gold standard" for determination of F.E. The accuracy of values of F.E determined using the reference tissue method was determined based on comparison with first-pass analysis. In some cases, deuterated water (D2O) was injected IV immediately after Gd-DTPA measurements, and the reference tissue method was used to calculate F, based on the rate of uptake of D2O. Comparison of rate constants for Gd-DTPA uptake and D2O uptake allowed calculation of EGd-DTPA Values for F.EGd-DTPA, F, and EGd-DTPA were determined for selected regions and on a pixel-by-pixel basis. Values for F.E and EGd-DTPA measured using the reference tissue method correlated well (P = .90 with a standard error of +/-.016, n = 15) with values determined based on first-pass contrast media uptake. The reference tissue method has important advantages: (a) A large volume of reference tissue can be used to determine the contrast agent input function with high precision. (b) Data obtained for 20 minutes after injection are used to calculate F or F.E. The greatly increased acquisition time can be used to increase the spatial resolution, held of view or SNR of measurements. The reference tissue method is most useful when the volume of tissue that must be imaged and/or the spatial resolution required precludes use of traditional first-pass methods.
引用
收藏
页码:1126 / 1134
页数:9
相关论文
共 50 条
[1]  
[Anonymous], 1967, NONEQUILIBRIUM THERM
[2]  
BARRATT TM, 1968, CLIN SCI, V35, P525
[3]   T2-WEIGHTED CONTRASTS IN RAPID LOW FLIP-ANGLE IMAGING [J].
BENDEL, P .
MAGNETIC RESONANCE IN MEDICINE, 1987, 5 (04) :366-370
[4]  
Claffey KP, 1996, CANCER RES, V56, P172
[5]   QUANTIFICATION OF MYOCARDIAL BLOOD-FLOW AND EXTRACELLULAR VOLUMES USING A BOLUS INJECTION OF GD-DTPA - KINETIC MODELING IN CANINE ISCHEMIC DISEASE [J].
DIESBOURG, LD ;
PRATO, FS ;
WISENBERG, G ;
DROST, DJ ;
MARSHALL, TP ;
CARROLL, SE ;
ONEILL, B .
MAGNETIC RESONANCE IN MEDICINE, 1992, 23 (02) :239-253
[6]   STUDIES OF GD-DTPA RELAXIVITY AND PROTON-EXCHANGE RATES IN TISSUE [J].
DONAHUE, KM ;
BURSTEIN, D ;
MANNING, WJ ;
GRAY, ML .
MAGNETIC RESONANCE IN MEDICINE, 1994, 32 (01) :66-76
[7]   VASCULAR-PERMEABILITY FACTOR, FIBRIN, AND THE PATHOGENESIS OF TUMOR STROMA FORMATION [J].
DVORAK, HF ;
NAGY, JA ;
BERSE, B ;
BROWN, LF ;
YEO, KT ;
YEO, TK ;
DVORAK, AM ;
VANDEWATER, L ;
SIOUSSAT, TM ;
SENGER, DR .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 667 :101-111
[8]   DISTRIBUTION OF BLOOD (FE-59) AND PLASMA (I-131) VOLUMES OF RATS DETERMINED BY LIQUID NITROGEN FREEZING [J].
EVERETT, NB ;
SIMMONS, B ;
LASHER, EP .
CIRCULATION RESEARCH, 1956, 4 (04) :419-424
[9]   CORRELATION BETWEEN CONTRAST ENHANCEMENT IN DYNAMIC MAGNETIC-RESONANCE-IMAGING OF THE BREAST AND TUMOR ANGIOGENESIS [J].
FROUGE, C ;
GUINEBRETIERE, JM ;
CONTESSO, G ;
DIPAOLA, R ;
BLERY, M .
INVESTIGATIVE RADIOLOGY, 1994, 29 (12) :1043-1049
[10]   GADOLINIUM-DTPA AS A CONTRAST AGENT IN MR IMAGING - THEORETICAL PROJECTIONS AND PRACTICAL OBSERVATIONS [J].
GADIAN, DG ;
PAYNE, JA ;
BRYANT, DJ ;
YOUNG, IR ;
CARR, DH ;
BYDDER, GM .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1985, 9 (02) :242-251