N-acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity

被引：108

作者：

Wakabayashi, H

Matsumoto, H

Hashimoto, K

Teraguchi, S

Takase, M

Hayasawa, H

机构：

[1] Morinaga Milk Ind Co Ltd, Nutr Sci Lab, Zama, Kanagawa 2288583, Japan

[2] Morinaga Milk Ind Co Ltd, Biochem Res Lab, Zama, Kanagawa 2288583, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 05期

关键词：

D O I：

10.1128/AAC.43.5.1267

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

N-acylated or D enantiomer peptide derivatives based on the sequence RRWQWRMKK in lactoferricin B demonstrated antimicrobial activities greater than those of lactoferricin B against bacteria and fungi. The most potent peptide, conjugated with an Ii-carbon-chain acyl group, showed two to eight times lower MIC than lactoferricin B.

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页码：1267 / 1269

页数：3

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