Zn- and Cd-metallothionein recombinant species from the most diverse phyla may contain sulfide (S2-) ligands

被引：66

作者：

Capdevila, M ^{[1
]}

Domènech, J

Pagani, A

Tío, L

Villarreal, L

Atrian, S

机构：

[1] Univ Autonoma Barcelona, Dept Quim, Fac Ciencies, E-08193 Barcelona, Spain

[2] Univ Barcelona, Fac Biol, Dept Genet, E-08028 Barcelona, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 29期

关键词：

bioinorganic chemistry; cadmium; metallothioneins; S ligands; zinc;

D O I：

10.1002/anie.200501183

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A sulfide surprise: The analysis of ZnII-, CdII-, and CuI-MT recombinant preparations of metallothioneins (MTs) from many organisms provides clear evidence that sulfide ions are present in nearly all their physiologically stable ZnII-MT and CdII-MT complexes (see picture), but in none of the CuI-MT species. The features of the MT complexes are in good correla(Chemical Equation Presented) tion with those reported for plant and yeast ZnII- or CdII-γ- glutamyl peptides. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4618 / 4622

页数：5

共 32 条

[1] Atypical neural messengers [J].

Barañano, DE ;

Ferris, CD ;

Snyder, SH .

TRENDS IN NEUROSCIENCES, 2001, 24 (02) :99-106

[2] CHEMICAL EVIDENCE FOR SYNCATALYTIC CONFORMATIONAL CHANGES IN ASPARTATE AMINOTRANSFERASE [J].

BIRCHMEIER, W ;

CHRISTEN, P .

FEBS LETTERS, 1971, 18 (02) :209-+

[3] How to hide zinc in a small protein [J].

Blindauer, CA ;

Sadler, PJ .

ACCOUNTS OF CHEMICAL RESEARCH, 2005, 38 (01) :62-69

[4] Zinc(ll) is required for the in vivo and in vitro folding of mouse copper metallothionein in two domains [J].

Bofill, R ;

Capdevila, M ;

Cols, N ;

Atrian, S ;

Gonzàlez-Duarte, P .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2001, 6 (04) :405-417

[5] A new insight into the Ag+ and Cu+ binding sites in the metallothionein β domain [J].

Bofill, R ;

Palacios, O ;

Capdevila, M ;

Cols, N ;

González-Duarte, R ;

Atrian, S ;

González-Duarte, P .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 73 (1-2) :57-64

[6] MICROMOLAR PROTEIN CONCENTRATIONS AND METALLOPROTEIN STOICHIOMETRIES OBTAINED BY INDUCTIVELY COUPLED PLASMA ATOMIC EMISSION SPECTROMETRIC DETERMINATION OF SULFUR [J].

BONGERS, J ;

WALTON, CD ;

RICHARDSON, DE ;

BELL, JU .

ANALYTICAL CHEMISTRY, 1988, 60 (24) :2683-2686

[7] Recombinant synthesis of mouse Zn3-beta and Zn4-alpha metallothionein 1 domains and characterization of their cadmium(II) binding capacity [J].

Capdevila, M ;

Cols, N ;

RomeroIsart, N ;

GonzalezDuarte, R ;

Atrian, S ;

GonzalezDuarte, P .

CELLULAR AND MOLECULAR LIFE SCIENCES, 1997, 53 (08) :681-688

[8] In vivo copper- and cadmium-binding ability of mammalian metallothionein β domain [J].

Cols, N ;

Romero-Isart, N ;

Bofill, R ;

Capdevila, M ;

Gonzàlez-Duarte, P ;

Gonzàlez-Duarte, R ;

Atrian, S .

PROTEIN ENGINEERING, 1999, 12 (03) :265-269

[9] Binding of excess cadmium(II) to Cd-7-metallothionein from recombinant mouse Zn-7-metallothionein 1. UV-VIS absorption and circular dichroism studies and theoretical location approach by surface accessibility analysis [J].

Cols, N ;

RomeroIsart, N ;

Capdevila, M ;

Oliva, B ;

GonzalezDuarte, P ;

GonzalezDuarte, R ;

Atrian, S .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1997, 68 (03) :157-166

[10] Metallothionein: The multipurpose protein [J].

Coyle, P ;

Philcox, JC ;

Carey, LC ;

Rofe, AM .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2002, 59 (04) :627-647

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