Familial predisposition and susceptibility to the effect of other risk factors for myocardial infarction

被引:29
作者
Hippe, M
Vestbo, J
Hein, HO
Borch-Johnsen, K
Jensen, G
Sorensen, TIA
机构
[1] Copenhagen Ctr Prospect Populat Studies, Copenhagen, Denmark
[2] Copenhagen Cty Ctr Prevent Med, Copenhagen, Denmark
[3] Copenhagen Univ Hosp, Epidemiol Res Unit, Dept Environm & Occupat Med, Copenhagen Male Study, Copenhagen, Denmark
[4] Copenhagen Univ Hosp, Danish Epidemiol Sci Ctr, Inst Prevent Med, Copenhagen K, Denmark
[5] Glostrup Univ Hosp, Copenhagen Cty Ctr Prevent Med, Dept Med C, Glostrup, Denmark
[6] Copenhagen Univ Hosp, Copenhagen City Heart Study, Epidemiol Res Unit, Dept Environm & Occupat Med, Copenhagen, Denmark
关键词
D O I
10.1136/jech.53.5.269
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Study objectives-To assess if familial predisposition to myocardial infarction (MI) is an indicator of increased susceptibility to the effect of other established risk factors. The study assessed whether a family history of MI modifies the effect of arterial blood pressure, plasma cholesterol, high and low density lipoprotein cholesterol, % triglycerides, diabetes mellitus, body mass index, height, smoking habits, alcohol intake, physical activity level, and educational level on the incidence of MI. Design-Prospective population based cohort study of cardiovascular risk and risk factors with follow up of MI by record linkage with the Cause of Death Register and The National Hospital Discharge Register until 1994. Setting-The Copenhagen Centre for Prospective Population Studies, where data from three Danish studies are integrated. Participants-Subjects were 24 664 people aged 20-93, examined between 1976 and 1987. Main results-A total of 1763 new cases of MI occurred during 293 559 person years of observation. All risk factors, including family history of MI reported by 4012 subjects, were, as expected, associated with incidence of MI. With a few inconsistent exceptions we found no significant interactions between family history of MI and cardiovascular risk factors in their effect on MI. Conclusions-The familial predisposition to MI does not consistently modify the effect of other risk factors on the risk of MI. However,.subjects with a family history of MI may still be regarded as an appropriate target group for screening for cardiovascular risk and intervention against other risk factors.
引用
收藏
页码:269 / 276
页数:8
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