Effect of experimental diabetes on rat prostate endothelin receptors

被引：22

作者：

Saito, M ^{[1
]}

Nishi, K ^{[1
]}

Foster, HE ^{[1
]}

Weiss, RM ^{[1
]}

Latifpour, J ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,UROL SECT,NEW HAVEN,CT 06520

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 310卷 / 2-3期

关键词：

endothelin receptor; diabetes; prostate; (rat);

D O I：

10.1016/0014-2999(96)00422-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the properties of endothelin receptors in the prostate of 8-week streptozotocin-diabetic and control rats. The density of endothelin receptors, as determined by saturation experiments with [I-125]endothelin-1, were 95.8 +/- 5.4 and 171.3 +/- 16.7 fmol/mg of protein in control and diabetic rat prostates, respectively. The pharmacological profile of the endothelin receptors was similar in both groups and was consistent with the predominance of the endothelin ET(A) receptor subtype in the prostate. Thus, the induction of diabetes upregulates the expression of endothelin receptors in the rat prostate, but does not alter the pharmacological profile of the receptors in these tissues.

引用

页码：197 / 200

页数：4

共 15 条

[1] SEXUAL FUNCTION IN DIABETIC-PATIENTS [J].