Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population

被引：91

作者：

Cadenhead, KS ^{[1
]}

Carasso, BS ^{[1
]}

Swerdlow, NR ^{[1
]}

Geyer, MA ^{[1
]}

Braff, DL ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

来源：

BIOLOGICAL PSYCHIATRY | 1999年 / 45卷 / 03期

关键词：

prepulse inhibition; habituation; reliability; startle; schizophrenia;

D O I：

10.1016/S0006-3223(98)00294-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prepulse inhibition (PPI) and habituation of the startle response are operational measures of sensorimotor gating and information processing. Changes in the normal inhibition ann habituation of the startle response may provide trait markers for illnesses such as schizophrenia that have altered neurotransmitter control of the neural circuitry that modulates these measures. The stability of PPI and habituation was assessed in 10 normal male subjects. Prepulse inhibition was found to be most stable in the more intense prepulse conditions, and habituation was most stable in the early portion of the test session. These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers. Biol Psychiatry 1999;45:360-364 (C) 1999 Society of Biological Psychiatry.

引用

页码：360 / 364

页数：5

共 19 条

[1] SENSORIMOTOR GATING AND HABITUATION EVOKED BY ELECTRO-CUTANEOUS STIMULATION IN SCHIZOPHRENIA
BOLINO, F
DIMICHELE, V
DICICCO, L
MANNA, V
DANELUZZO, E
CASACCHIA, M
[J]. BIOLOGICAL PSYCHIATRY, 1994, 36 (10) : 670 - 679
[2] STARTLE REFLEX HABITUATION IN FUNCTIONAL PSYCHOSES - A CONTROLLED-STUDY
BOLINO, F
MANNA, V
DICICCO, L
DIMICHELE, V
DANELUZZO, E
ROSSI, A
CASACCHIA, M
[J]. NEUROSCIENCE LETTERS, 1992, 145 (02) : 126 - 128
[3] PRE-STIMULUS EFFECTS ON HUMAN STARTLE REFLEX IN NORMALS AND SCHIZOPHRENICS
BRAFF, D
STONE, C
CALLAWAY, E
GEYER, M
GLICK, I
BALI, L
[J]. PSYCHOPHYSIOLOGY, 1978, 15 (04) : 339 - 343
[4] BRAFF DL, 1995, CLIN NEUROSCI, V3, P131
[5] BRAFF DL, 1992, ARCH GEN PSYCHIAT, V49, P206
[6] CADENHEAD KS, 1993, AM J PSYCHIAT, V150, P1862
[7] Cronbach LJ, 1951, PSYCHOMETRIKA, V16, P297
[8] STARTLE HABITUATION AND SENSORIMOTOR GATING IN SCHIZOPHRENIA AND RELATED ANIMAL-MODELS
GEYER, MA
BRAFF, DL
[J]. SCHIZOPHRENIA BULLETIN, 1987, 13 (04) : 643 - 668
[9] HABITUATION OF THE BLINK REFLEX IN NORMALS AND SCHIZOPHRENIC-PATIENTS
GEYER, MA
BRAFF, DL
[J]. PSYCHOPHYSIOLOGY, 1982, 19 (01) : 1 - 6
[10] STARTLE RESPONSE MODELS OF SENSORIMOTOR GATING AND HABITUATION DEFICITS IN SCHIZOPHRENIA
GEYER, MA
SWERDLOW, NR
MANSBACH, RS
BRAFF, DL
[J]. BRAIN RESEARCH BULLETIN, 1990, 25 (03) : 485 - 498

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