Cytotoxic dolabellane diterpenes from the formosan soft coral Clavularia inflata

被引：48

作者：

Duh, CY ^{[1
]}

Chia, MC

Wang, SK

Chen, HJ

El-Gamal, AAH

Dai, CF

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 80424, Taiwan

[2] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung, Taiwan

[3] Natl Taiwan Univ, Inst Oceanol, Taipei 10764, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 08期

关键词：

D O I：

10.1021/np010106n

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Six new cytotoxic dolabellane diterpenes, (1R*,12R*)-dolabella-4(16),7,10-triene-3,13-dione (1), (1R*,7R*,8S*,12R*)-dolabella-4(16),10-diene-7,8-epoxy- 3,13-dione (3), (1R*),10R*,11S*,12R*)-dolabella-4(16),7-diene10.11-epoxy-3,13-dione (3), (1R*)-dolabella-4(16),7,11(12)-triene-3,13-dione (4), (1R*,3R*)-3-hydroxydolabella-4(16),7,11(12)-triene-3,13-dione (5), and (1R*,7R*)-7-hydroperoxydolabella-4(16),8(17),11(12)-triene-3,13-dione (6), have been isolated from the Formosan soft coral Clavularia inflata. The structures of compounds 1-6 were determined by 1D and 2D spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.

引用

页码：1028 / 1031

页数：4

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