Benzannelation alters the rate limiting step in enediyne cycloaromatization

被引：50

作者：

Kaneko, T

Takahashi, M

Hirama, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

[2] Japan Sci & Technol Corp, CREST, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 10期

关键词：

Bergman reactions; radicals and radical reactions; steric and strain effects; aromaticity;

D O I：

10.1016/S0040-4039(99)00105-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rate-limiting step in the Bergman reaction was changed from cyclization to hydrogen-abstraction by benzannelation. This effect should be attributed to the faster rate of the retro-Bergman cyclization and/or the slower rate of hydrogen abstraction by the aromatic ring condensed 1,4-didehydrobenzene intermediate. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2015 / 2018

页数：4

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