Pathway specificity for Met signalling

被引：79

作者：

Comoglio, PM ^{[1
]}

机构：

[1] Univ Turin, Sch Med, Inst Canc Res, I-10060 Turin, Italy

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 07期

关键词：

D O I：

10.1038/35083116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Signals generated by the tyrosine kinase receptor Met elicit a complex biological response Including cell dissociation, migration, protection from apoptosis, proliferation and differentiation. Paradoxically, all these are triggered by phosphorylation of a single two-tyrosine motif in the Met receptor tail, docking-multiple SH2 signal transducers. The precise amino acid sequence of the motif is an absolute requirement for fulfilling the response, showing that there is specificity in intracellular pathways.

引用

页码：E161 / E162

页数：2

共 16 条

[1] Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth [J].

Bardelli, A ;

Longati, P ;

Gramaglia, D ;

Basilico, C ;

Tamagnone, L ;

Giordano, S ;

Ballinari, D ;

Michieli, P ;

Comoglio, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14379-14383

[2] Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase [J].

Birchmeier, C ;

Gherardi, E .

TRENDS IN CELL BIOLOGY, 1998, 8 (10) :404-410

[3] Oncogenic kinase signalling [J].

Blume-Jensen, P ;

Hunter, T .

NATURE, 2001, 411 (6835) :355-365

[4] Induction of epithelial tubules by growth factor HGF depends on the STAT pathway [J].

Boccaccio, C ;

Andò, M ;

Tamagnone, L ;

Bardelli, A ;

Michieli, P ;

Battistini, C ;

Comoglio, PM .

NATURE, 1998, 391 (6664) :285-288

[5] Scatter factors and invasive growth [J].

Comoglio, PM ;

Boccaccio, C .

SEMINARS IN CANCER BIOLOGY, 2001, 11 (02) :153-165

[6] Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes [J].

Fambrough, D ;

McClure, K ;

Kazlauskas, A ;

Lander, ES .

CELL, 1999, 97 (06) :727-741

[7] A point mutation in the MET oncogene abrogates metastasis without affecting transformation [J].

Giordano, S ;

Bardelli, A ;

Zhen, Z ;

Menard, S ;

Ponzetto, C ;

Comoglio, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13868-13872

[8] Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis [J].

Gual, P ;

Giordano, S ;

Williams, TA ;

Rocchi, S ;

Van Obberghen, E ;

Comoglio, PM .

ONCOGENE, 2000, 19 (12) :1509-1518

[9] Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway [J].

Khwaja, A ;

Lehmann, K ;

Marte, BM ;

Downward, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (30) :18793-18801

[10] Coupling met to specific pathways results in distinct developmental outcomes [J].

Maina, F ;

Panté, G ;

Helmbacher, F ;

Andres, R ;

Porthin, A ;

Davies, AM ;

Ponzetto, C ;

Klein, R .

MOLECULAR CELL, 2001, 7 (06) :1293-1306

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