DNA methylation landscapes: provocative insights from epigenomics

被引：2187

作者：

Suzuki, Miho M. ^{[1
]}

Bird, Adrian ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrg2341

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.

引用

页码：465 / 476

页数：12

共 106 条

[1] ANTEQUERA A, 1993, DNA METHYLATION MOL, P169
[2] NUMBER OF CPG ISLANDS AND GENES IN HUMAN AND MOUSE
ANTEQUERA, F
BIRD, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11995 - 11999
[3] Gene-associated CpG islands in plants as revealed by analyses of genomic sequences
Ashikawa, I
[J]. PLANT JOURNAL, 2001, 26 (06) : 617 - 625
[4] ACTIVE MAIZE GENES ARE UNMODIFIED AND FLANKED BY DIVERSE CLASSES OF MODIFIED, HIGHLY REPETITIVE DNA
BENNETZEN, JL
SCHRICK, K
SPRINGER, PS
BROWN, WE
SANMIGUEL, P
[J]. GENOME, 1994, 37 (04) : 565 - 576
[5] Whole-genome re-sequencing
Bentley, David R.
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (06) : 545 - 552
[6] High-throughput DNA methylation profiling using universal bead arrays
Bibikova, M
Lin, ZW
Zhou, LX
Chudin, E
Garcia, EW
Wu, B
Doucet, D
Thomas, NJ
Wang, YH
Vollmer, E
Goldmann, T
Seifart, C
Jiang, W
Barker, DL
Chee, MS
Floros, J
Fan, JB
[J]. GENOME RESEARCH, 2006, 16 (03) : 383 - 393
[7] DNA methylation patterns and epigenetic memory
Bird, A
[J]. GENES & DEVELOPMENT, 2002, 16 (01) : 6 - 21
[8] BIRD A, 1985, CELL, V40, P91, DOI 10.1016/0092-8674(85)90312-5
[9] Perceptions of epigenetics
Bird, Adrian
[J]. NATURE, 2007, 447 (7143) : 396 - 398
[10] Methylation-induced repression - Belts, braces, and chromatin
Bird, AP
Wolffe, AP
[J]. CELL, 1999, 99 (05) : 451 - 454

← 1 2 3 4 5 6 7 8 9 10 →