Hydrolytic kinetic resolution of α-naphthyl glycidyl ether:: A practical access to highly enantioselective β-adrenergic blocking agents

被引：11

作者：

Bose, DS ^{[1
]}

Reddy, AVN ^{[1
]}

Chavhan, SW ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 2, Fine Chem Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2005年 / 14期

关键词：

naphthyl glycidyl ether; hydrolytic kinetic resolution; naftopidil; propranolol; terminal epoxide;

D O I：

10.1055/s-2005-870021

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kinetic resolution of (+/-)-naphthyl glycidyl ether using 0.5 mol% (R,R)-salen Co(III)OAc and water (0.55 equiv) provided enantiomerically pure naphthyl glycidyl ether and 1-naphthylglycerol derivatives with high enantiomeric excess. Application of this approach to highly enantioenriched (S)-naftopidil and (S)-propranolol is described.

引用

页码：2345 / 2348

页数：4

共 23 条

[1]

[Anonymous], CATALYTIC ASYMMETRIC

[2] PRACTICAL CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF PROPRANOLOL [J].