Synthesis of the biaryl moiety of the proteasome inhibitors TMC-95 via a ligandless Pd(OAc)2-catalyzed Suzuki-coupling reaction

被引：44

作者：

Ma, DW ^{[1
]}

Wu, QQ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 31期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0040-4039(01)00966-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biaryl moiety of proteasome inhibitors TMC-95 was synthesized via a Pd(OAc)(2)-catalyzed Suzuki-coupling reaction of 7-iodoisatin and a tyrosine-derived arylboronic acid in the absence of phosphine ligands using potassium fluoride as a base. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5279 / 5281

页数：3

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